Metabolic Targeting of SREBP1 Reprograms the Obesity-Driven Ascites Immune Microenvironment and Enhances Chemotherapy Response in Obesity-Associated Ovarian Cancer
Jing Yang, Tyvette S. Hilliard, Yueying Liu, Emily Richardson, SOPHIA SANTOSO, Viktoriia Khomenko, Molly B. Conroy, BRANDON MARTIN, Emily Cronberger, Gena M. Dominique, Zhikun Wang, JEFFREY JOHNSON, Wanrui Wang, Ijeoma Asilebo, Mary Sharon Stack
This study shows that inhibiting SREBP1 with Nelfinavir improves chemotherapy response in obesity-associated ovarian cancer by reprogramming the immune microenvironment.
bioRxiv · Sep 16, 2026 · PreprintCancer Biology