Genetic & Genomic MedicinemedRxivPreprint
Genetic Variation at 19q13.33 confers colorectal cancer risk through the interaction of mucosal expression of FUT2 and plasma vitamin B12 levels
DOI 10.64898/2026.07.10.26357741
Author
Kevin Donnelly
Edinburgh Cancer ResearchORCID 0000-0001-7633-9113Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2021-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 shared papersGenetic & Genomic Medicine
Malcolm G. DunlopORCID
Mutual co-authors in cluster
6 papers
Recent·Most cited
- Cancer BiologybioRxivPreprint
Lymph-node transcriptomics define prognostic immune states in mucosal melanoma and reveal IBA1 as a practical biomarker for improved prognosis
Angus Lane, Laura Blackwood, Kevin Donnelly…·Kelly Bowlt Blacklock
This study identifies two prognostic lymph node subgroups in canine oral mucosal melanoma using transcriptomics, with IBA1 expression linked to improved survival.
DOI 10.1101/2025.09.20.677500 - GeneticsGutPeer-reviewed
Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2
Vidya Rajasekaran, Bradley T. Harris, Ruby Tamara Osborn…·Susan Mary Farrington
This study identifies rs3087967 as the causal variant at 11q23.1 that increases colorectal cancer risk by dysregulating POU2AF2, a key activator of tuft cell transcription.
- GenomicsbioRxivPreprint
Exploring the association between Body Mass Index, Sex and Gene Expression in human colorectal epithelium
Lea Lemler, Kevin Donnelly, Ian P.M. Tomlinson…·Malcolm G. Dunlop
The paper analyzes gene expression in normal colorectal mucosa to assess associations with BMI and sex, finding no significant associations after replication.
DOI 10.1101/2022.11.21.515057 - BioinformaticsbioRxivPreprint
Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression in silico
Bradley T. Harris, Vidya Rajasekaran, James Peter Blackmur…·Susan Mary Farrington
The paper investigates the relationship between 11q23.1 eQTL targets and tuft cell abundance using scRNA-seq data, finding a correlation between gene expression and cluster-specific tuft cell markers.
- Genetic & Genomic MedicineBMC MedicinePeer-reviewed
Oral Vitamin D supplementation induces transcriptomic changes in rectal mucosa that are consistent with anti-tumour effects.
Peter G Vaughan-Shaw, Graeme R. Grimes, James Peter Blackmur…·Malcolm G. Dunlop
This study shows oral vitamin D supplementation changes rectal mucosa gene expression patterns linked to anti-tumor effects, with blood biomarkers HIPK2 and PPP1CC identifying responders.
10 citations