Author

James Peter Blackmur

Edinburgh Cancer ResearchORCID 0000-0001-7267-837XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Farhat V. N. DiniD· 3 shared Kevin DonnellyiD· 3 shared Malcolm G. DunlopiD· 3 shared Maria N TimofeevaiD· 3 shared Peter G Vaughan-ShawiD· 3 shared Susan Mary FarringtoniD· 3 shared Bradley T. HarrisiD· 2 shared Graeme R. GrimesiD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Farhat V. N. DinORCID

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3 papers

Recent·Most cited

GeneticsGutPeer-reviewedNov 28, 2024

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2

Vidya Rajasekaran, Bradley T. Harris, Ruby Tamara Osborn…·Susan Mary Farrington

This study identifies rs3087967 as the causal variant at 11q23.1 that increases colorectal cancer risk by dysregulating POU2AF2, a key activator of tuft cell transcription.

8 citations

humanmouse

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BioinformaticsbioRxivPreprintMar 29, 2022

Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression in silico

Bradley T. Harris, Vidya Rajasekaran, James Peter Blackmur…·Susan Mary Farrington

The paper investigates the relationship between 11q23.1 eQTL targets and tuft cell abundance using scRNA-seq data, finding a correlation between gene expression and cluster-specific tuft cell markers.

DOI 10.1101/2022.03.29.485182

humanscRNA-seq

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Genetic & Genomic MedicineBMC MedicinePeer-reviewedAug 2, 2021

Oral Vitamin D supplementation induces transcriptomic changes in rectal mucosa that are consistent with anti-tumour effects.

Peter G Vaughan-Shaw, Graeme R. Grimes, James Peter Blackmur…·Malcolm G. Dunlop

This study shows oral vitamin D supplementation changes rectal mucosa gene expression patterns linked to anti-tumor effects, with blood biomarkers HIPK2 and PPP1CC identifying responders.

10 citations

humanbulk RNA-seq

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