Genetic & Genomic MedicinemedRxivPreprint
Genetic Variation at 19q13.33 confers colorectal cancer risk through the interaction of mucosal expression of FUT2 and plasma vitamin B12 levels
DOI 10.64898/2026.07.10.26357741
Author
Farhat V N Din
Edinburgh Cancer ResearchORCID 0000-0001-5466-8282Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2021-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 shared papersGenetic & Genomic Medicine
Malcolm G. DunlopORCID
Mutual co-authors in cluster
7 papers
Recent·Most cited
- GeneticsGutPeer-reviewed
Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2
Vidya Rajasekaran, Bradley T. Harris, Ruby Tamara Osborn…·Susan Mary Farrington
This study identifies rs3087967 as the causal variant at 11q23.1 that increases colorectal cancer risk by dysregulating POU2AF2, a key activator of tuft cell transcription.
- Developmental BiologybioRxivPreprint
Non-gonadal PIWI protein, Aubergine, regulates regenerative stem cell proliferation and tumourigenesis in the Drosophila adult intestine.
Karen Bellec, Lynsey Rose Carroll, Kathryn A.F. Pennel…·Julia B. Cordero
This study shows Aubergine regulates ISC proliferation and tumourigenesis in Drosophila intestine through protein synthesis, independent of its piRNA function.
DOI 10.1101/2024.11.04.621896 - GenomicsbioRxivPreprint
Factors influencing patterns of gene expression in large bowel mucosa
Peter G Vaughan-Shaw, Li Yin Ooi, Maria N Timofeeva…·Malcolm G. Dunlop
This study identifies demographic and sampling factors affecting gene expression in normal colorectal mucosa, with age, gender, and sample site showing significant associations.
1 citation - BioinformaticsbioRxivPreprint
Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression in silico
Bradley T. Harris, Vidya Rajasekaran, James Peter Blackmur…·Susan Mary Farrington
The paper investigates the relationship between 11q23.1 eQTL targets and tuft cell abundance using scRNA-seq data, finding a correlation between gene expression and cluster-specific tuft cell markers.
- Genetic & Genomic MedicineBMC MedicinePeer-reviewed
Oral Vitamin D supplementation induces transcriptomic changes in rectal mucosa that are consistent with anti-tumour effects.
Peter G Vaughan-Shaw, Graeme R. Grimes, James Peter Blackmur…·Malcolm G. Dunlop
This study shows oral vitamin D supplementation changes rectal mucosa gene expression patterns linked to anti-tumor effects, with blood biomarkers HIPK2 and PPP1CC identifying responders.
10 citations