Author

Yang Xiao

ORCID 0000-0001-7635-9552Unclaimed ORCID profile · follow to get notified of new preprints

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Yang Xiao3 papers · Fudan University

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Bin XiiD· 2 shared Bo HuangiD· 2 shared Han WangiD· 2 shared Wei FengiD· 2 shared Zhenming LiuiD· 2 shared Bowen ZhangiD· 1 shared Cheng ShiiD· 1 shared Chuanyu LiuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioinformatics

Bin XiORCID

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2 papers

Recent·Most cited

A closed-loop reinforcement learning framework for rapid compound directed optimization

Han Wang, Dehua Lu, Weiping Lyu, Siyu Xiu, Cheng Shi, Xiaonan Zhou, Bin Xi, Wei Feng, Yang Xiao, Yanming Chen, Haixian Zhang, Qi Li, Bo Huang, Zhenming Liu

This paper introduces RCDO, a closed-loop reinforcement learning framework that accelerates compound optimization by integrating experimental feedback with generative models, achieving significant improvements in drug candidate properties.

bioRxiv · Aug 27, 2026 · PreprintBioinformatics

A unified language model bridging de novo and fragment-based 3D molecule design delivers potent CBL-B inhibitors for cancer treatment

Han Wang, Guocheng Sun, Bowen Zhang, Yang Wang, Bin Xi, Minjian Yang, Chuanyu Liu, Yuyang Ge, Fan Fan, Wei Feng, Yanhao Zhu, Yang Xiao, Yuji Wang, Zhenming Liu, Daohua Jiang, , Bo Huang

bioRxiv · Nov 13, 2025 · PreprintBioinformatics