Author

Daohua Jiang

Chinese Academy of SciencesORCID 0000-0002-4397-5807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Bin XiiD· 2 shared Bo HuangiD· 2 shared Bowen ZhangiD· 2 shared Guocheng SuniD· 2 shared Han WangiD· 2 shared Huting WangiD· 2 shared Wenbiao ZhouiD· 2 shared Yang WangiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Bin XiORCID

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3 papers

Recent·Most cited

A unified language model bridging de novo and fragment-based 3D molecule design delivers potent CBL-B inhibitors for cancer treatment

Han Wang, Guocheng Sun, Bowen Zhang, Yang Wang, Bin Xi, Minjian Yang, Chuanyu Liu, Yuyang Ge, Fan Fan, Wei Feng, Yanhao Zhu, Yang Xiao, Yuji Wang, Zhenming Liu, Daohua Jiang, , Bo Huang

bioRxiv · Nov 13, 2025 · PreprintBioinformatics

Pocket-based molecule generation with an SE(3)-equivariant language model leads to a potent and selective HPK1 inhibitor with in vivo efficacy

Bin Xi, Han Wang, Guocheng Sun, Bowen Zhang, Ruihan Mao, Yuyang Ge, Yang Wang, Jiangtao Zhang, Yiting Pan, Feng Zhou, Yuji Wang, Zhenming Liu, Daohua Jiang, Huting Wang, Wenbiao Zhou, Bo Huang

bioRxiv · Sep 23, 2025 · PreprintBioinformatics

Gating mechanism of human N-type voltage-gated calcium channel

Yanli Dong, Yiwei Gao, Shuai Xu, Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Yuan Tian, Bei Yang, Xuejun Cai Zhang, Daohua Jiang, Zhuo Huang, Yan Zhao

The paper presents a cryo-EM structure of the human CaV2.2 complex, revealing the closed-state inactivation mechanism through the blocking-ball formed by the W-helix.

Cell Reports · Nov 1, 2021Peer-reviewedNeuroscience