Author

Liel Sapir

Bar-Ilan UniversityORCID 0000-0001-7652-6541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alon RainishiD· 2 shared Masha Y. NiviD· 2 shared Dominic R. HuxleyiD· 1 shared Donna MatzoviD· 1 shared Dorothée WeikertiD· 1 shared Fabrizio FierroiD· 1 shared Harald HübneriD· 1 shared Lior PeriiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Alon RainishORCID

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2 papers

Recent·Most cited

Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR

Alon Rainish, Liel Sapir, Masha Y. Niv

The paper uses molecular dynamics simulations to study how ligand binding at two sites of TAS2R14 affects receptor dynamics and chloride ion behavior.

Journal of Chemical Information and Modeling · Sep 3, 2026Peer-reviewedBioinformatics

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14

Lior Peri, Donna Matzov, Dominic R. Huxley, Alon Rainish, Fabrizio Fierro, Liel Sapir, Tara Pfeiffer, Lukas A. W. Waterloo, Harald Hübner, Yoav Peleg, Peter Gmeiner, Peter James McCormick, Dorothée Weikert, Masha Y. Niv, Moran Shalev-Benami

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

Nature Communications · Nov 18, 2024Peer-reviewedBiochemistry