Peter James McCormick

A network-based atlas of human skeletal muscle aging

This paper develops a network-based atlas of human skeletal muscle aging using transcriptomic data from 1,675 biopsies and multiple single-cell technologies, revealing gene modules and interactions associated with aging and load status.

MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor

This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

Elucidating the activation mechanism of the proton-sensing GPR68 receptor

This study investigates the activation mechanism of GPR68 using computational and in vitro methods, identifying key residues and structural changes involved in pH-dependent activation.

The Batten disease protein CLN3 is important for stress granules dynamics and translational activity.

This study shows that CLN3 deficiency disrupts stress granule dynamics and translation, linking it to neurodegenerative disease mechanisms.

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington’s disease

This study identifies D1R-H3R heteromers as a therapeutic target for Huntington’s disease by showing their role in dopamine signaling and their modulation by H3R antagonists.