Yoav Peleg

The paper reports cryo-EM structures of Na+,K+-ATPase isoforms and a disease-causing mutant, revealing conformational states and functional properties related to Na+ transport and disease mechanisms.

The paper develops hMultiCLEM, a high-resolution screening pipeline combining EM and multiplexed human cell pools to identify proteins affecting mitochondrial cristae shape, uncovering MISHA linked to Meniere's disease.

This study shows that TECPR2 loss causes mitochondrial dysfunction and mitophagy impairment in HSAN9, which can be mitigated by ISR suppression.

The paper identifies an unconventional Pex5-Eci1 interaction interface that enables PTS1-independent peroxisomal import of Eci1 in yeast.

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

The paper identifies an amphipathic helix as a targeting motif for ER surface proteins in yeast and humans, showing its conservation and role in membrane localization.