Jörg J. Goronzy

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

The paper examines how aging affects antigen-specific memory CD8+ T cells in EBV infection, finding distinct aging trajectories with changes in gene expression and TCR diversity.

Aging primarily impairs the CD8+ T cell VZV vaccine response, while effective VZV vaccination in older adults induces antigen-specific Th17 CD4+ T cells to compensate for aging defects.

NEAT-seq profiles nuclear proteins, chromatin accessibility, and transcriptomes in single cells, revealing TF regulatory mechanisms and linking GWAS SNPs to chromatin accessibility and target genes.