Alexander T. Heubeck

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

CryoSCAPE enables scalable immune profiling using cryopreserved whole blood for multi-omic single cell and functional assays, demonstrating compatibility with high-throughput RNA sequencing and functional testing.