Probir Chakravarty

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

This study identifies BDNF as a key signal for pituitary stem cell differentiation and homeostasis in mouse models of glucocorticoid deficiency.

The paper identifies immune signatures in TB contacts that predict protection or progression to active TB using single-cell RNA sequencing and correlates findings with non-human primate data.

This study shows that booster vaccination enhances plasma cell durability by shifting their fate toward long-lived states rather than just increasing numbers.

The paper uses a human Trunk-like Structure (hTLS) model to study interactions between somites and neural tube during trunk development, showing endogenous signaling and dose-dependent ventralization.

This study shows that Arpc5-containing Arp2/3 complexes are critical for macrophage function and maintaining host-microbiota homeostasis, as their loss leads to intestinal inflammation.

The paper identifies neuronal mimicry in cancer-associated fibroblasts driven by calcium waves, leading to immune exclusion, and shows that blocking this process restores immune control.

This study identifies neutrophil-driven systemic conditioning that links inflammation, tissue regeneration, and metastasis, with UPP1 as a key factor in neutrophil priming.

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

The study compares CSF and blood transcriptomes in pneumococcal meningitis patients to identify mortality-associated inflammatory responses.

This study shows anti-activin treatment reduces desmoplastic barriers and increases T cell infiltration in tumors, improving survival in SMAD4-null pancreatic cancer models.

The paper identifies a subpopulation of bone marrow macrophages that support AML growth by inhibiting T cells and are enriched in patients with early relapse.

This paper shows SOX2 induces fetal reprogramming and reversible dormancy in colorectal cancer, promoting tumour progression and drug tolerance.

The paper shows that most gonadotrophs in adults originate from postnatal pituitary stem cells during minipuberty, while embryonic gonadotrophs are maintained, revealing a dual origin.

The paper uses single-cell technologies to study pituitary stem cell heterogeneity and shows that differentiation is more frequent and diverse than previously thought, with maintenance of progeny dependent on the microenvironment.

The paper identifies how SETX mutations cause genome instability in AOA2 by increasing transcription stress and impairing repair mechanisms.

This study investigates the role of ELP1 in neuronal development by analyzing transcriptomes of mouse embryos with varying ELP1 levels, finding that ELP1 regulates gene expression and neuronal development.

The paper identifies spatial and molecular differences in cardiac progenitor origins in mouse embryos, showing distinct regions of the primitive streak contribute to different heart structures.