De novo design of potent CRISPR-Cas13 inhibitors
Cyntia Taveneau, Her Xiang Chai, Jovita D’Silva…·Gavin J. Knott
This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.
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Monash UniversityORCID 0000-0001-7685-713XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Cyntia Taveneau, Her Xiang Chai, Jovita D’Silva…·Gavin J. Knott
This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.
Roland W. Calvert, Brooke K. Hayes, Her Xiang Chai…·Gavin J. Knott
The paper determines the structure of tRNA-bound CRISPR-Cas13 and reveals universal HEPN RNase mechanisms for substrate recognition and catalysis.
Jillian F. Banfield, Luis E. Valentin-Alvarado, Ling-Dong Shi…·Gavin J. Knott
The paper analyzes Borg archaeal extrachromosomal elements using in silico methods, revealing features similar to giant eukaryotic viruses, suggesting convergent evolution.