De novo design of potent CRISPR-Cas13 inhibitors
Cyntia Taveneau, Her Xiang Chai, Jovita D’Silva…·Gavin J. Knott
This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.
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Monash UniversityORCID 0000-0002-6942-785XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Cyntia Taveneau, Her Xiang Chai, Jovita D’Silva…·Gavin J. Knott
This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.
Roland W. Calvert, Brooke K. Hayes, Her Xiang Chai…·Gavin J. Knott
The paper determines the structure of tRNA-bound CRISPR-Cas13 and reveals universal HEPN RNase mechanisms for substrate recognition and catalysis.
Valeriya Bezkorovayna, Brooke K. Hayes, Francesca N. Gillett…·John D. Boyce
This study identifies the molecular function and delivery determinants of the T6SS effector Tae17 in Acinetobacter baumannii, showing it is a bifunctional peptidoglycan hydrolase with lytic transglycosylase and amidase activities.