Author

Roland W. Calvert

Monash UniversityORCID 0000-0002-8709-848XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Brooke K. HayesiD· 2 shared Cyntia TaveneauiD· 2 shared Gavin J. KnottiD· 2 shared Her Xiang ChaiiD· 2 shared Joseph RosenbluhiD· 2 shared Jovita D’SilvaiD· 2 shared Rebecca S. BamertiD· 2 shared Chen DavidovichiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Brooke K. HayesORCID

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Author profile →

2 papers

Recent·Most cited

De novo design of potent CRISPR-Cas13 inhibitors

Cyntia Taveneau, Her Xiang Chai, Jovita D’Silva, Rebecca S. Bamert, Honglin Chen, Brooke K. Hayes, Roland W. Calvert, Jacob Purcell, Daniel J. Curwen, Fabian Munder, Lisandra L. Martin, Jeremy J. Barr, Joseph Rosenbluh, Mohamed Fareh, Rhys Grinter, Gavin J. Knott

This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.

Nature Chemical Biology · Jan 26, 2026Peer-reviewedBiochemistry

Structures of tRNA-bound CRISPR-Cas13 reveal universal HEPN RNase mechanisms

Roland W. Calvert, Brooke K. Hayes, Her Xiang Chai, Yongyi Peng, Cheng Huang, Hariprasad Venugopal, Cyntia Taveneau, Jovita D’Silva, Joseph Rosenbluh, Chen Davidovich, Chris Greening, Rebecca S. Bamert, Gavin J. Knott

The paper determines the structure of tRNA-bound CRISPR-Cas13 and reveals universal HEPN RNase mechanisms for substrate recognition and catalysis.

bioRxiv · Dec 3, 2025 · PreprintBiochemistry