Philip Charles Biggin

The paper identifies ligands with varying steric profiles that exhibit different β-arrestin recruitment capacities at GPR84, revealing a mechanism for controlling signaling bias.

This study identifies a potent and selective TRPC3 inhibitor, GSK2820986A, and elucidates its binding mechanism through molecular dynamics and functional assays.

This study identifies the molecular mechanisms of GqPCR-mediated inhibition of TASK-1 and TASK-3 K2P channels and links their dysfunction to disease.

This study identifies how TC-2559, a super-agonist, modulates the high sensitivity nicotinic acetylcholine receptor through both orthosteric and allosteric binding sites, enhancing channel opening.

This paper introduces an algorithm using ellipsoidal probe particles to better characterize ion channel pore geometry, revealing that non-spherical probes improve conductance predictions compared to spherical ones.

This study uses molecular dynamics simulations to elucidate the conformational mechanism and proton-substrate coupling in mammalian POTs, revealing key structural differences and functional insights.

This study develops screening assays for modulating kainate receptors GluK1-3 and provides structural insights into GluK3's ligand-binding domain.

The paper identifies structural residues in the δ subunit of human muscle nicotinic acetylcholine receptors that influence subunit assembly and functional dynamics.