Christian D. P. Klein

Antiviral Drug Discovery with an Optimized Biochemical Dengue Protease Assay: Improved Predictive Power for Antiviral Efficacy

This study improves the predictive power of a biochemical dengue protease assay for antiviral efficacy by optimizing conditions and evaluating phenylglycine-based inhibitors.

Alternate recognition by dengue protease: Proteolytic and binding assays provide functional evidence beyond an induced-fit

The paper provides functional evidence that dengue protease recognizes substrates and inhibitors primarily through conformational selection rather than induced-fit, highlighting the impact of experimental conditions on ligand binding and proteolysis.