Tina Roostaei

This study evaluates a cryopreservation protocol for CSF cells, showing it preserves cell composition and transcriptomes effectively, enabling multi-center research.

The paper identifies glucocorticoid-responsive molecular defects in MS T cells through cell-type-specific transcriptomic profiling and validates potential therapeutic targets.

This study identifies disease-enriched microglial subsets and validates compounds that modulate their states using single-cell RNA sequencing and in vitro experiments.

The paper identifies mQTL effects of MS susceptibility loci on DNA methylation in CD4+ T cells, revealing both cis and trans regulatory impacts.

The paper examines microglial activation in elderly brains, finding strong associations with neuropathology and cognitive decline, and identifies genetic overlaps with Alzheimer's disease.