Hans‐Ulrich Klein

The paper develops a post-processing workflow combining Xenium spatial technology with 4i imaging to enable multi-omic mapping of post-mortem human brain tissue, focusing on pathological microenvironments.

The paper presents an xQTL atlas of regulatory variation in the aging human brain, integrating multiple modalities and cell types across four studies, identifying more variant-molecular-trait associations by including TAD boundaries.

This study investigates the genetic overlap between inflammatory bowel disease and Alzheimer's disease, finding distinct myeloid cell-specific risk factors and some protective associations.

The paper uses single-cell data to identify factors regulating an Alzheimer's disease-related microglial signature and proposes a new analytic framework for microglial classification.

This study identifies genetic covariance between early-onset Alzheimer's disease and lipid traits, highlighting three novel loci and potential causative genes.

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

The paper identifies a SERPINA3-expressing astrocytic state in the human neocortex near neuritic plaques using spatial transcriptomic analysis.

The paper quantifies somatic mitochondrial DNA insertions (Numts) in human brain and fibroblasts, showing their accumulation over time and association with lifespan.

The paper derives cell-type-specific Alzheimer's disease polygenic risk scores and shows their associations with distinct pathological features in AD.

This study shows ZCCHC17 regulates RNA splicing in neurons and its dysfunction contributes to splicing abnormalities in Alzheimer's disease, with potential therapeutic implications.

demuxmix improves demultiplexing of scRNA-seq data by using regression mixture models to better handle background noise and improve assignment accuracy.

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

The paper identifies two subtypes of aging brains with distinct Alzheimer's risk profiles and differential impacts of APOEε4.

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

The paper identifies glucocorticoid-responsive molecular defects in MS T cells through cell-type-specific transcriptomic profiling and validates potential therapeutic targets.

This study identifies disease-enriched microglial subsets and validates compounds that modulate their states using single-cell RNA sequencing and in vitro experiments.

The paper identifies mQTL effects of MS susceptibility loci on DNA methylation in CD4+ T cells, revealing both cis and trans regulatory impacts.

Coexpression meta-analysis of 2114 human brain RNA-seq samples across the AMP-AD consortium identifies five consensus Alzheimer's disease transcriptional clusters, including two sex-heterogeneous clusters and a previously unreported proteostasis cluster.

This study identifies tau pathology-driven chromatin organization changes in aged human brains and shows these effects can be reversed with HSP90 inhibitors.

Molecular network analysis of RNA sequencing data from the aging human cortex identifies new Alzheimer's and cognitive decline genes.

The paper identifies gene modules in human frontal cortex microglia associated with beta-amyloid and tau pathology in Alzheimer's disease.

The paper identifies xQTLs in the human brain integrating RNA, DNA methylation, and histone acetylation data from 411 individuals, revealing 18 new CNS disease susceptibility loci.