Julie A. Schneider

Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer's disease heterogeneity

This study integrates multi-omics data from aged human brains to identify cross-system biological factors and molecular subtypes associated with Alzheimer's disease heterogeneity.

Multi-omics characterization of vascular, neurodegenerative, and mixed neuropathology in the aging human brain

This study identifies molecular programs distinguishing vascular, neurodegenerative, and mixed pathology in aging human brains using proteomic and transcriptomic data.

Blood-brain barrier dysfunction predicts cognitive trajectory after ischemic stroke

The paper identifies a plasma proteomic signature linked to blood-brain barrier dysfunction, which predicts cognitive decline after ischemic stroke.

HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization

This study investigates the role of the HEXIM1/P-TEFb complex in regulating RNA polymerase II pause release and immediate early gene induction in neurons during depolarization.

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina

The paper identifies Chlamydia pneumoniae infection and NLRP3 inflammasome activation in Alzheimer's disease retinas, linking them to disease progression and cognitive impairment.

Single Cell Landscape of Sex-specific Drivers of Alzheimers Disease

This study identifies sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive decline using single-nucleus RNA sequencing from human brain tissue.

Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimers Disease

The paper identifies cell type-specific gene modules associated with Alzheimer's Disease traits using snRNASeq data from human brain tissues.

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance

The paper examines sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive performance using bulk transcriptomic data from 767 individuals.

Cytokine expression profile in the human brain of older adults

This study examines cytokine gene expression in human brain tissue from elderly individuals with and without Alzheimer's disease to identify biomarkers and understand disease mechanisms.

Automated image segmentation uncovers the role of CD74high human microglia in cognitive decline

The paper uses automated image segmentation to identify CD74high microglia associated with cognitive decline in AD, linking transcriptomic and morphological features.

A proteogenomic tool uncovers protein markers for human microglial states

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature

The paper uses single-cell data to identify factors regulating an Alzheimer's disease-related microglial signature and proposes a new analytic framework for microglial classification.

Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans

This study translates post-mortem brain multi-omics AD dementia subtypes into blood, MRI, and psychological markers in living individuals.

Structural variants linked to Alzheimer's Disease and other common age-related clinical and neuropathologic traits

The paper investigates structural variants (SVs) in AD/ADRD traits using whole genome sequencing data from two cohort studies, identifying SVs linked to disease phenotypes and suggesting new risk loci.

Multi-omic subtypes of Alzheimer's dementia are differentially associated with psychological traits

The paper examines associations between three multi-omic AD subtypes and four psychological traits, finding differential links between subtypes and traits.

Sex, racial, and APOE-ϵ4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease

The paper examines how sex, race, and APOE-ε4 allele status affect white matter microstructure across multiple aging and Alzheimer's disease cohorts.

Association of 10 VEGF Family Genes with Alzheimer's Disease Endophenotypes at Single Cell Resolution

This study investigates the role of 10 VEGF genes in Alzheimer's disease using single-nucleus RNA sequencing, finding altered expression and associations with disease endophenotypes.

Polygenic Risk Associated with Alzheimer's Disease and Other Traits Influences Genes Involved in T Cell Signaling and Activation

The paper computes polygenic risk scores for various disorders and correlates them with T cell gene expression in Alzheimer's patients and controls, identifying gene pathways related to T cell signaling and activation.

CHRNA5 links chandelier cells to severity of amyloid pathology in human aging and Alzheimer's Disease

The paper investigates CHRNA5's role in amyloid pathology in aging and Alzheimer's by analyzing genetic variants and cell-type expression in human brain tissue.

Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease

The paper derives cell-type-specific Alzheimer's disease polygenic risk scores and shows their associations with distinct pathological features in AD.

The Caribbean-Hispanic Alzheimer's Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

The paper analyzes RNA-seq data from Caribbean-Hispanic Alzheimer's patients and controls to identify ancestry-specific gene expression patterns associated with disease.

Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

Bulk and Single-nucleus Transcriptomics Highlight Intra-telencephalic and Somatostatin Neurons in Alzheimer's Disease

The paper identifies somatostatin and intra-telencephalic neurons as significantly associated with Alzheimer's disease using bulk and single-nucleus transcriptomics across multiple datasets.

A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization.

This study identifies disease-enriched microglial subsets and validates compounds that modulate their states using single-cell RNA sequencing and in vitro experiments.

RNA-sequencing of human post-mortem hypothalamus and nucleus accumbens identifies expression profiles associated with obesity.

The paper identifies differentially expressed mRNAs and microRNAs in human brain tissues associated with obesity and BMI using RNA sequencing from multiple cohorts.

Genome-wide association study and functional validation implicates JADE1 in tauopathy

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

The paper evaluates methods for estimating cell-type proportions in brain tissue using paired transcriptomic and immunohistochemistry data, showing some algorithms provide accurate estimates.

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

The paper uses multiplexed proteomics to identify synaptic factors linked to cognitive resilience in Alzheimer's Disease by analyzing brain tissue from individuals with varying pathology and cognitive outcomes.

Genetic Variants and Functional Pathways Associated with Resilience to Alzheimer's Disease

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.