Pia Kivisäkk

This paper introduces SPEAR, a separation-free protein detection method that achieves sub-100-molecule sensitivity using engineered kinetic proofreading, outperforming existing methods for Alzheimer's and SARS-CoV-2 biomarkers.

The paper shows that low-dose carbon monoxide reduces Parkinson's disease pathology in rodent models by activating HO-1, similar to the protective effect observed in smokers.

This study identifies novel plasma biomarkers for Alzheimer's disease and related dementias using unbiased proteomics in a large cohort.

The paper identifies glucocorticoid-responsive molecular defects in MS T cells through cell-type-specific transcriptomic profiling and validates potential therapeutic targets.

The paper identifies mQTL effects of MS susceptibility loci on DNA methylation in CD4+ T cells, revealing both cis and trans regulatory impacts.