Howard L. Weiner

The paper identifies NKG2C+CD27- as a novel marker for CD8+ regulatory T cells, revealing their clonality and functional subsets, and highlights their heterogeneity in aging.

This study shows nasal anti-CD3 antibody treatment reduces neuroinflammation, enhances neurogenesis, and improves cognitive function in a mouse model of Long COVID.

This study identifies XPC as essential for protecting Th17 cells from oxidative DNA damage, showing its role in DNA repair, differentiation, and function.

This study shows that ODC1 suppresses age-associated B cell features in meningeal inflammation of MS and EAE, affecting disease severity.

The paper finds that ApoE ε4-dependent changes in CXCR3+CD127+ CD4+ T cells in peripheral blood correlate with elevated neurofilament light chain in Alzheimer's disease.

This study shows vancomycin improves EAE recovery by altering gut microbiota, indole derivatives, and secondary bile acids, which modulate mTOR pathway gene expression in astrocytes.

This study identifies 236 MS susceptibility variants and highlights neuronal and glial dysfunction as key factors in MS susceptibility.

The paper identifies glucocorticoid-responsive molecular defects in MS T cells through cell-type-specific transcriptomic profiling and validates potential therapeutic targets.

This study identifies CD4 T and B cells as driver cell subsets in multiple sclerosis using chromatin accessibility data and genetic fine-mapping.

The paper identifies mQTL effects of MS susceptibility loci on DNA methylation in CD4+ T cells, revealing both cis and trans regulatory impacts.