Graeme J. Thorn

This study benchmarks three low-input whole exome sequencing workflows for ctDNA profiling in PDAC, showing Agilent V8 provides best performance in low-input settings.

This study examines breast cancer differences between African, South Asian, and European ancestries, finding earlier onset, different tumor characteristics, and varied mutation patterns.

This study identifies patient-specific and common nucleosome repositioning patterns in breast cancer tissues and links them to cancer pathways and liquid biopsy applications.

The paper develops a chromatin hierarchical lattice framework to predict heterochromatin nanodomains and identifies DNA sequence and protein binding factors that determine their formation and boundaries.

The paper shows that Cnot1 regulates nuclear poly(A) tail size of serum-induced mRNAs, revealing a role in both transcription and deadenylation.