Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb and reverses HIV-1 latency
Mateusz Stoszko, Abdullah M. S. Al‐Hatmi, Anton Škríba, Michael D. Röling, Enrico Ne, Raquel Crespo, Yvonne M. Mueller, Mohammad Javad Najafzadeh, Joyce Kang, Renata Ptáčková, Elizabeth H LeMasters, Pritha Biswas, Alessia Bertoldi, Tsung Wai Kan, Elisa De Crignis, , Tokameh Mahmoudi
The paper identifies gliotoxin as a novel LRA that disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency in CD4+ T cells.
Science Advances · Aug 12, 2020Peer-reviewedMolecular Biology