Cell BiologyNucleic Acids ResearchPeer-reviewed
The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity
Hasan Mamar, Roberta Fajka‐Boja, Mónika Mórocz…·Gyula Timinszky
This study shows that loss of POLE4 leads to PARP inhibitor sensitivity independent of BRCA1, through replication stress and DNA-PK signaling changes.
13 citations