Adaptive immunity is dispensable for salamander appendage regeneration
Chimezie H. Umeano, Marlene J. Oesterle, Ameneh Ghaffarinia…·Nicholas D. Leigh
Rag1-knockout newts lacking adaptive immunity regenerate larval limbs, tails and adult limbs without overt gross differences from controls; newt blastema tolerates allografts, and axolotl regenerating limbs show immunosuppressive transcriptional shifts.