Author

Emma Bolech

GenentechORCID 0009-0006-4656-3636Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Adam D LonghurstiD· 1 shared Ameneh GhaffariniaiD· 1 shared András SimoniD· 1 shared Becky Xu Hua FuiD· 1 shared Bence DánieliD· 1 shared Benjamin L. Lusk· 1 shared Camila Rosat ConsiglioiD· 1 shared Chimezie H. Umeano· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

Adam D LonghurstORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 8, 2026

✦ In-depth digest

Adaptive immunity is dispensable for salamander appendage regeneration

Chimezie H. Umeano, Marlene J. Oesterle, Ameneh Ghaffarinia…·Nicholas D. Leigh

Rag1-knockout newts lacking adaptive immunity regenerate larval limbs, tails and adult limbs without overt gross differences from controls; newt blastema tolerates allografts, and axolotl regenerating limbs show immunosuppressive transcriptional shifts.

1 citation

multiple speciesmouse

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Cell BiologyEMBO ReportsPeer-reviewedJul 14, 2026

The regulation of Protein Phosphatase 4 by FBXO42 is required for cancer cell survival.

Stephan H. Spangenberg, Nicholas Garaffo, Enya Marie Catherine Alcindor…·David Paul Toczyski

This study identifies FBXO42's role in regulating PPP4C and p53 signaling, showing its importance in cancer cell survival through genetic and proteomic analyses.

3 citations

humanproteomics

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ImmunologybioRxivPreprintSep 23, 2025

IRF2 degradation tunes the innate immune response

Cristhian Cadena, Rohit Reja, Emma Bolech…·Vishva M. Dixit

The paper shows IRF2 degradation by IRF1 during immune responses enhances ISG transcription, revealing a regulatory circuit between IRF1 and IRF2 in innate immunity.

DOI 10.1101/2025.09.23.678148

mousehuman

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