Measurement of cellular traction forces during confined migration
Max A. Hockenberry, Andrew J. Ulmer, Johann L. Rapp, Harrison H. Truscott, Frank A. Leibfarth, James E. Bear, Wesley R. Legant
This study measures cellular traction forces during confined migration through tunable microscale geometries, revealing that softer constrictions cause greater nuclear deformation due to internal contractile forces.
Proceedings of the National Academy of Sciences · Nov 25, 2025Peer-reviewedBiophysics