Wesley R. Legant

The paper investigates how actin-membrane interface stress regulates Arp2/3-branched actin density during lamellipodial protrusion in response to extracellular conditions.

This paper introduces a reconfigurable microscopy module that combines HIST and line-scanning confocal techniques for versatile fluorescence imaging.

The paper shows that hydrodynamic dispersion in porous media enhances viral-cellular collisions, improving transduction efficiency by overcoming sedimentation-diffusion limitations.

This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

This study shows that SUN2 in the nucleus regulates endothelial cell-matrix interactions, affecting vascular homeostasis and barrier function through microtubule and matrix metalloprotease mechanisms.

This paper introduces a series of spontaneously blinking dyes with adjustable duty cycles for improved single-molecule localization microscopy in cells and dense structures.

This study measures cellular traction forces during confined migration through tunable microscale geometries, revealing that softer constrictions cause greater nuclear deformation due to internal contractile forces.

The paper develops a multiplexed imaging protocol to map nuclear organization at multiple scales, revealing distinct spatial correlations and organizational principles at nanoscale and microscale levels.

This paper introduces a method to detect and correct axial offset between excitation and detection focal planes in latticeSIM to reduce image artifacts.

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.