Author

Irene Beusch

University of California, San FranciscoORCID 0000-0001-7758-4348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Beiduo RaoiD· 2 shared Hiten D. MadhaniiD· 2 shared Alma L. BurlingameiD· 1 shared Bradley A. BowseriD· 1 shared Daniela S. PerryiD· 1 shared Em SeGravesiD· 1 shared Jade Sales-LeeiD· 1 shared John R. YatesiD· 1 shared

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2021-2022 · peak 1/yr

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2 shared papersMolecular Biology

Beiduo RaoORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 13, 2022

Targeted high throughput mutagenesis of the human spliceosome reveals its in vivo operating principles

Irene Beusch, Beiduo Rao, Michael K. Studer…·Hiten D. Madhani

This study uses CRISPR-Cas9 base editing to target the human spliceosome and identifies functional sites and resistance substitutions, revealing SUGP1's role in spliceosome disassembly.

1 citation

humanCRISPR screen

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Molecular BiologyCurrent BiologyPeer-reviewedSep 22, 2021

Coupling of spliceosome complexity to intron diversity

Jade Sales-Lee, Daniela S. Perry, Bradley A. Bowser…·Hiten D. Madhani

The paper identifies conserved spliceosomal proteins in fungi and humans that regulate splicing efficiency and suppress weak splice sites, suggesting a role in enabling intron diversity through error limitation.

53 citations

yeasthuman

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