Jade Sales-Lee

The paper identifies optimized protein-based enhancers of HDR in human HSPCs through functional screening, improving HDR efficiency without increasing off-target effects.

The paper identifies conserved spliceosomal proteins in fungi and humans that regulate splicing efficiency and suppress weak splice sites, suggesting a role in enabling intron diversity through error limitation.

The paper shows that start codon context regulates translation in fungi, affecting uORF usage and dual-protein localization.

The paper identifies five novel genes required for RNAi-mediated transposon suppression in C. neoformans, revealing a non-Dicer RNase III and nucleolar factors involved in endo-siRNA biogenesis.

The paper develops a method to profile spliceosome-bound RNA at nucleotide resolution in yeast, revealing non-canonical splicing events and substrate features influencing catalytic efficiency.