Beiduo Rao

This study identifies a biophysical mechanism for mitochondrial pearling, showing it occurs spontaneously in various cell types and is driven by internal pressure or external tension.

This study uses CRISPR-Cas9 base editing to target the human spliceosome and identifies functional sites and resistance substitutions, revealing SUGP1's role in spliceosome disassembly.

The paper reveals the structural mechanism of ATP-dependent DNA methylation by DNMT5, showing how hemimethylated DNA activates the SNF2 ATPase domain and remodels the catalytic pocket for specificity.

The paper identifies conserved spliceosomal proteins in fungi and humans that regulate splicing efficiency and suppress weak splice sites, suggesting a role in enabling intron diversity through error limitation.

The paper identifies five novel genes required for RNAi-mediated transposon suppression in C. neoformans, revealing a non-Dicer RNase III and nucleolar factors involved in endo-siRNA biogenesis.

The paper develops a method to profile spliceosome-bound RNA at nucleotide resolution in yeast, revealing non-canonical splicing events and substrate features influencing catalytic efficiency.