Lu Hong

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

This paper introduces an evolutionary multiobjective optimization framework for protein sequence design, combining AlphaFold2 and ProteinMPNN to improve sequence recovery in complex design problems.

The paper uses Bayesian modeling to show that ultrasensitivity in KaiC phosphorylation, driven by differential KaiA binding to ATP/ADP states, enables metabolic compensation in the cyanobacterial circadian clock.