Aaron R. Dinner

The paper uses neural likelihood ratio estimation to infer activator-inhibitor dynamics in Rho GTPase activity from perturbation experiments in frog eggs.

This paper investigates ultrafast contraction in Spirostomum using myonemes, showing centrin-Sfi1 structures drive calcium-triggered contraction without actomyosin or ATP.

The paper identifies bistability in the cyanobacterial circadian clock as a mechanism for temperature compensation, linking it to amplitude regulation and phosphorylation dynamics.

The paper investigates how tau protein coordinates microtubule-actin interactions in synthetic cell-like vesicles, showing its role in MT organization and MT-actin colocalization depending on actin crosslinkers and vesicle size.

This paper develops light-controlled chemomechanical networks using Tcb2 protein to achieve rapid, repeatable actuation and dynamic self-assembly.

This study shows chronic infections can generate SARS-CoV-2-like mutation bursts without epistasis, increasing global evolutionary rates.

The paper develops an activator-inhibitor model to show how actin network heterogeneity tunes RhoA activity patterns across different organisms.

The paper identifies target-specific fitness landscapes in protein-protein interactions and develops a supervised contrastive learning approach to predict binders.

The paper uses agent-based simulations calibrated with microscopy data to predict and validate how microscopic actin dynamics affect cortical flow speed in C. elegans zygotes.

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

The paper analyzes insulin dimer dissociation using a computational framework to identify pathways and quantify their contributions to the dissociation rate.

The paper shows that highly charged protein regions often form structured helices, challenging the assumption that they are disordered, and introduces a better classifier for predicting structure in these regions.

This study shows that dietary restriction in Drosophila affects diurnal rhythms and longevity through clock-controlled proteasome subunits.

The paper uses Bayesian modeling to show that ultrasensitivity in KaiC phosphorylation, driven by differential KaiA binding to ATP/ADP states, enables metabolic compensation in the cyanobacterial circadian clock.

The paper improves rhythm detection in sparsely sampled genome-wide expression time series using bootstrapping and empirical Bayes methods, showing better consistency than existing methods.

The paper addresses the issue of dependent p-values in rhythm detection methods for genome-wide expression time series and proposes corrections for accurate statistical significance estimation.