Lei Chen

This study identifies coordinated suppression of HNF4α and HNF4γ as an epithelial-intrinsic barrier defect in ileal Crohn's disease, reversible with HNF4 agonists.

The paper identifies dynamic RNA Polymerase II recruitment as the main driver of transcriptomic changes during intestinal differentiation, with HNF4 playing a key role in this process.

The paper identifies HNF4 factors as critical for fetal intestinal maturation, showing their role in chromatin accessibility and gene regulation during the embryonic-to-fetal transition.

This study shows CDX2 has different chromatin-binding profiles in embryonic and adult intestines, leading to distinct gene activation patterns and developmental outcomes.