Coordinated HNF4α and HNF4γ Suppression Defines a Reversible Ileal Epithelial Barrier Defect in Crohn,s Disease
Debasish Halder, Amin Esmaeilniakooshkghazi, Chiranjeevi Padala, Yaohong Wang, Jason Ken Hou, Xia Qiu, Lei Chen, Michael Paul Verzi, Seema Khurana
This study identifies coordinated suppression of HNF4α and HNF4γ as an epithelial-intrinsic barrier defect in ileal Crohn's disease, reversible with HNF4 agonists.
bioRxiv · Oct 27, 2025 · PreprintPathology