PathologybioRxivPreprint
Coordinated HNF4α and HNF4γ Suppression Defines a Reversible Ileal Epithelial Barrier Defect in Crohn,s Disease
Debasish Halder, Amin Esmaeilniakooshkghazi, Chiranjeevi Padala…·Seema Khurana
This study identifies coordinated suppression of HNF4α and HNF4γ as an epithelial-intrinsic barrier defect in ileal Crohn's disease, reversible with HNF4 agonists.