Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold
Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D. Caro, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello
The paper uses cryo-EM to show that tau filaments in Down syndrome share the same structure as those in Alzheimer's disease.
Acta Neuropathologica Communications · Jun 12, 2024Peer-reviewedNeuroscience