Author
University of California, Los AngelesORCID 0000-0001-7833-165XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Swetha Ramesh, Chenlu Di, Kirk E. Lohmueller
This study detects pervasive cryptic negative selection in human noncoding regions using a statistical test, finding that at least 7% of the genome is under negative selection, surpassing previous estimates from conservation-based methods.
Chenlu Di, Swetha Ramesh, Jason Ernst, Kirk E. Lohmueller
The paper infers the fitness effects of noncoding mutations in humans using genomic annotations and polymorphism data, finding distinct selection patterns across different noncoding regions.
Sasilada Sirirungruang, Omer Ad, Thomas M. Privalsky…·Michelle C. Y. Chang
This paper describes engineering a fluorine-selective enzyme to produce fluorinated polyketide analogs using E. coli.