Chaitan Khosla

This study shows that enterovirus infection induces TG2 via JAK-STAT signaling in intestinal epithelial cells, linking viral infection to celiac disease onset.

This study identifies intestinal CD103+ dendritic cells as key players in TG2-mediated gluten antigen presentation in celiac disease and shows their role in activating T cells and upregulating TG2 activity.

The paper investigates intermodular communication in polyketide biosynthesis using cryo-EM and crosslinking, revealing structural insights for designing hybrid synthases.

This paper describes engineering a fluorine-selective enzyme to produce fluorinated polyketide analogs using E. coli.

The paper identifies polyketide biosynthetic gene clusters likely to encode novel antibiotics by analyzing self-resistance genes across genomes.

A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.