John Stagg

This study identifies PRMT7 as a negative regulator of CD8+ T cell immunity and demonstrates a PROTAC degrader (MS54) that enhances anti-tumor responses by activating the NF-κB pathway.

This paper develops a distributed pipeline for immuno-oncology biomarker discovery using federated learning to integrate clinical and molecular data across institutions without sharing sensitive data.

The paper shows DNA demethylating agents enhance CD8+ T cell cytolytic activity and anti-tumor immunity through dsRNA sensing pathway activation.