Cancer BiologyNeuro-Oncology AdvancesPeer-reviewed
Combined inhibition of SHP2 overcomes adaptive resistance to type 1 BRAF inhibitors in BRAF V600E-driven high-grade glioma
Abiola Abdulrahman Ayanlaja, Michael Chang, Kriti Lalwani…·Karisa C. Schreck
This study shows that combining SHP2 inhibition with BRAF inhibitors overcomes resistance in BRAF V600E-driven gliomas by suppressing RAS/ERK signaling and preventing tumor growth.
6 citations