Jonathan A. Brassard

This paper develops a method to create vascularized bioartificial organs using 3D printing and polymer casting, demonstrating its application in creating a functional pancreas for diabetes treatment.

The paper describes a method to create cm-scale perfusable endocrine pancreatic tissues using sacrificial embedded 3D printing in alginate, showing viability and insulin secretion in cultured beta cells.

The paper introduces an accessible platform to measure oxygen diffusion in cell-laden hydrogels and applies it to alginate-immobilized pancreatic beta cells, showing reduced diffusion coefficients with higher gel concentration.

This study develops human pancreatic organoids from pluripotent stem cells that recapitulate pancreatic development, including ductal network formation and endocrine cell generation.