Daniel O. Kechele

This study develops human pancreatic organoids from pluripotent stem cells that recapitulate pancreatic development, including ductal network formation and endocrine cell generation.

This study uses human pluripotent stem cell-derived hindgut cultures to show that WNT signaling directs dorsal-ventral patterning, promoting urothelial fate over colorectal fate.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

This study uses human organoids to show RFX6 mutations cause duodenal malformations by disrupting PDX1 and other signaling pathways.

The paper develops a method to engineer functional human gastrointestinal organoids by assembling cells from the three primary germ layers, revealing the role of the enteric nervous system in tissue development.

This study uses patient-derived organoids to identify new pathologies in individuals with PDX1 mutations, revealing intestinal and gastric metaplasia.