Gut barrier defects, increased intestinal innate immune response, and enhanced lipid catabolism drive lethality in N-glycanase 1 deficient Drosophila
Ashutosh N. Pandey, Antonio Galeone, Seung Yeop Han, Benjamin A. Story, Gaia Consonni, William F. Mueller, Lars Michael Steinmetz, Thomas Vaccari, Hamed Jafar‐Nejad
This study shows that loss of Drosophila N-glycanase 1 causes gut barrier defects, leading to immune activation and lipid catabolism, which contribute to lethality through non-infectious mechanisms.
bioRxiv · Apr 7, 2023 · PreprintDevelopmental Biology