Developmental BiologybioRxivPreprint
Gut barrier defects, increased intestinal innate immune response, and enhanced lipid catabolism drive lethality in N-glycanase 1 deficient Drosophila
Ashutosh N. Pandey, Antonio Galeone, Seung Yeop Han…·Hamed Jafar‐Nejad
This study shows that loss of Drosophila N-glycanase 1 causes gut barrier defects, leading to immune activation and lipid catabolism, which contribute to lethality through non-infectious mechanisms.
DOI 10.1101/2023.04.07.536022