The importance of UBQLN2 ubiquitylation for its turnover and localization
Martin Grønbæk-Thygesen, Caroline Kampmeyer, Paula Eschger, Michael H. Tatham, Marloes Arts, Kay Hofmann, Kresten Lindorff‐Larsen, Wouter Boomsma, Rasmus Hartmann‐Petersen
This study shows that ubiquitylation of UBQLN2's UBL domain regulates its stability and localization, with implications for proteasomal degradation and ALS.
Biochemistry · Dec 22, 2025Peer-reviewedBiochemistry