Iosif M. Gershteyn

The paper proposes the Decoherence via Demyelination Hypothesis (DDH) to explain age-related cognitive decline through tract-specific myelin loss and its impact on neural network coordination.

This study evaluates the cytotoxic mechanism of IMV-M, a MUC16 x DR5 bispecific antibody, showing that multivalent MUC16 binding is required for cytotoxicity and that CA125 does not neutralize its activity.

This paper introduces a bispecific antibody, IMV-M, that effectively clusters DR5 on MUC16-positive tumor cells without secondary crosslinking, showing potent anti-tumor activity in vitro and xenograft models.