Kaitlin Blackstone Casaletto

Large-scale cerebrospinal fluid proteomics identifies diagnostic biomarker candidates across the clinico-pathological continuum of frontotemporal lobar degeneration

The paper identifies potential diagnostic biomarkers for frontotemporal lobar degeneration subtypes using cerebrospinal fluid proteomics.

Decoherence via Demyelination Hypothesis (DDH): A Mechanism of Cognitive Decline During Aging

The paper proposes the Decoherence via Demyelination Hypothesis (DDH) to explain age-related cognitive decline through tract-specific myelin loss and its impact on neural network coordination.

A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain

The paper identifies a proteomic signature linked to vascular dysfunction and neurodegeneration in aging brains, highlighting thromboinflammation as an early pathway to tauopathy.

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy

This study identifies plasma proteomic signatures associated with repetitive head impact exposure and CTE, linking them to immune, mitochondrial, and metabolic pathways and cognitive decline.

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

This study examines sex differences in clinical progression of autosomal dominant frontotemporal dementia, finding females show more rapid declines in symptomatic stages and less sensitive NfL prognostic value.

Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia

This study identifies a mechanism by which progranulin deficiency leads to mitochondrial hyperfusion and neuroinflammation in GRN-FTD, showing that targeting C3aR can restore mitochondrial integrity and reduce microglial activation.

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

Sexually dimorphic differences in angiogenesis markers predict brain aging trajectories

The paper examines associations between circulating angiogenesis markers and brain aging trajectories in humans, finding sex-specific effects and implications for vascular cognitive impairment.

Endothelial-derived exosomes demonstrate a link between endothelial innate inflammation and brain dysfunction and injury in aging

The paper examines endothelial-derived exosomes in older adults to link endothelial inflammation with white matter injury, cognition, and brain degeneration.