Joel H. Kramer

The paper identifies the CSF YWHAG:NPTX2 ratio as a biomarker for predicting clinical severity and phenoconversion in FTLD, showing strong correlation with disease progression and improved trial design potential.

The paper proposes the Decoherence via Demyelination Hypothesis (DDH) to explain age-related cognitive decline through tract-specific myelin loss and its impact on neural network coordination.

This study identifies functional network changes in neurodegenerative diseases using MRI data, linking brain atrophy to specific connectivity patterns and cognitive deficits.

The paper identifies a proteomic signature linked to vascular dysfunction and neurodegeneration in aging brains, highlighting thromboinflammation as an early pathway to tauopathy.

This study identifies plasma proteomic signatures associated with repetitive head impact exposure and CTE, linking them to immune, mitochondrial, and metabolic pathways and cognitive decline.

This study identifies a mechanism by which progranulin deficiency leads to mitochondrial hyperfusion and neuroinflammation in GRN-FTD, showing that targeting C3aR can restore mitochondrial integrity and reduce microglial activation.

This study uses event-based sequencing models to analyze neural oscillation trajectories in Alzheimer's disease stages, finding frequency-specific synchrony changes linked to early neurodegeneration and cognitive decline.

This study investigates the association between enlarged perivascular spaces (ePVS) and white matter injury, brain atrophy, cognitive decline, and inflammation markers in CADASIL, finding ePVS correlates with these pathologies and specific plasma proteins.

The paper investigates C9orf72 expansion carriers using radiogenomics to link peripheral blood transcriptomics with thalamic atrophy and clinical impairment, finding global transposable element de-repression and associations between C9orf72 expression and disease severity.

This study uses ex vivo diffusion MRI and histopathology to correlate tract disruptions with axonal injury in a TBI patient.

The paper links neuron type-specific TDP-43 pathology in the frontoinsular cortex to salience network atrophy and loss of empathy in frontotemporal dementia.

The paper identifies four time-varying functional connectivity modes in the anterior insula that exhibit both state and trait characteristics, relating to empathy and brain connectivity patterns.

This study examines the association between COMT Val158Met polymorphism and susceptibility to framing effects in older adults, finding a significant link that diminishes after adjusting for demographic factors.

The paper examines endothelial-derived exosomes in older adults to link endothelial inflammation with white matter injury, cognition, and brain degeneration.